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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Anesthesiology. 2016 Jul;125(1):147–158. doi: 10.1097/ALN.0000000000001134

Figure 8.

Figure 8

Flumazenil can inhibit the enhancement of GABA currents by isoflurane. A, Representative traces of GABA receptor activation in multiple treatment conditions. Black bars represent co-application of isoflurane; orange bars represent co-application of increasing flumazenil concentrations (from left to right: 0.1, 0.3, 1.0, 3.0, 10, 30 μM). Inset is an overlay of EC20 GABA response (black), EC20 GABA response potentiated by isoflurane (280 μM), and the flumazenil antagonized EC20 GABA response potentiated by isoflurane. B, Summative dose-response curve for the effect of increasing doses of flumazenil on isoflurane enhanced EC20 response (n = 34 cells). Error bars represent SEM.