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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Anesthesiology. 2016 Jul;125(1):147–158. doi: 10.1097/ALN.0000000000001134

Figure 9.

Figure 9

Flumazenil exhibits weak agonist effects on the GABA receptor in the absence of GABA. A, Representative traces of chloride currents through the GABA receptor evoked by application of increasing flumazenil concentrations (orange bars, from left to right: 0.1, 0.3, 1.0, 3.0, 10, 30 μM) followed by the response of the GABA receptor to a 10 μM application of GABA (EC20) for comparison. B, Summative dose-response curve for flumazenil’s effect on the GABA receptor in the absence of GABA (n = 10 cells). Error bars represent SEM.