Figure 1.

Asymmetric distribution of core planar cell polarity proteins. Core PCP proteins localize asymmetrically along cell boundaries as indicated (inset). Fmi or Celsr1 displays axial asymmetry where it localizes to intercellular junctions oriented along one tissue axis but is excluded from orthogonal junctions. In contrast, Vang-Prickle and Frizzled-Dishevelled-Diego complexes adopt vectorial asymmetries where each complex localizes to opposite poles of the cell.