Skip to main content
. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Cell Biol. 2016 Aug 26;44:110–116. doi: 10.1016/j.ceb.2016.08.002

Figure 3.

Figure 3

Interdependent relationship between the orientation of junctional remodeling and the Fmi/Celsr1 polarity axis. (a) The global axis of PCP across the wing blade reorients with hinge contraction, during which oriented cell divisions and cell rearrangements occur. These morphogenetic changes reorient the PCP axis from a radial to proximal-distal orientation. The new PCP axis aligns parallel to the orientation of new cell-cell junctions. Schematic adapted from [52]. (b) Schematic depiction of how oriented junction formation, functioning to relax tissue strain during skin morphogenesis, could define Celsr1 polarity axis in developing mouse embryonic skin.