Figure 2.

Schematic illustration of in vivo ¹⁷O MR technique for quantifying CMRO₂ and CBF in rodents via a brief inhalation of ¹⁷O-labeled oxygen gas: the principle (a), quantification model and mass balance equation (b), as well as the simplified method for calculating CMRO₂ and CBF based on the brain H₂¹⁷O time course (c) are displayed. Detailed description and explanation of the method can be found in references [38–39 & 40–43].