Figure 1.

Disulfide compounds from asafetida inhibit the proliferation of human melanoma cells A375. A375 cells were treated with increasing concentration (10–30–100 μM) of several disulfide compounds (propionyl deacylasadisulfide, PDA; acetyl deacylasadisulfide, ADA; foetisulfide A, FSA; arachyl deacylasadisulfide, ARDA; deacylasadisulfide, DA) and one no sulfur-containing compound (methoxylatifolone, MEF). Growth inhibition was measured at 72 h using the MTT assay and is expressed as OD values. All the compounds tested, with the only exception of the MEF, inhibited the proliferation of melanoma cells although with different potency. Experiments were run in triplicate, each performed in quadruplicate (^*P < 0.05; ^***P < 0.001 vs. control [CTRL]).