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ADA inhibits B16 melanoma metastasis in vivo. B16-F10 mouse melanoma cells were injected through the lateral tail vein of C57BL/6J mice (n = 8 per group). ADA (5 or 50 mg·kg−1) was given orally to mice; control mice received vehicle only. ADA 5 and 50 mg·kg−1 reduced the metastatic area by 60 and 96% respectively. (A) Representative macroscopic pictures of mouse lungs, 14 days after inoculation. (B) Histogram with the percentage of metastatic affected area.
