ADAR Involvement in Cell Proliferation and Apoptosis
(A) Western blot analysis of ADAR silencing after shRNA lentiviral transduction in MDA-MB-231, MCF7, and BT474 breast cancer cell lines.
(B) ADAR silencing statistically decreases cell proliferation. Cell growth curves for ADAR-knockdown cells (shRNA ADAR) and control cells (shRNA control) in MDA-MB-231, MCF7, and BT474 BC cell lines.
(C) ADAR silencing statistically increases cell apoptosis. Illustration of the percentage of apoptotic cells in ADAR-knockdown cells (shRNA ADAR) and control cells (shRNA control) in MDA-MB-231, MCF7, and BT474 BC cell lines. Error bars depict SDs of three independent experiments.