Figure 7.

ADAR Amplification and the Interferon Response Predict ADAR Expression in Human Cancers

We included all TCGA data sets and tumors (see “N” column) for which both copy-number and RNA-seq expression data (pipeline v.3) were available. Data sets are ordered by decreasing median ADAR expression (top to bottom). The three leftmost plots depict the distributions of ADAR expression, ADAR DNA copy number, and STAT1 expression across each data set. The two rightmost bar plots extend to TCGA data the calculation presented for our data in Figures 5B and 5C. In most cancers, adjusting ADAR expression for ADAR copy number increases the Spearman correlation, ρ, with STAT1 (cf. the dark blue bars to the light blue bars).