Table 1.

Summary of studies investigating the impact of curcumin treatment in models of muscular injury

Reference	Model	Curcumin dose	Type of injury	Duration of treatment	Route of administration	Main result
53	C57BL/6 mice	20 µg/kg/day	Freeze injury in masseter muscle	Single dose	Intraperitoneal injection	Regeneration of muscle fibres
83	C57BL/6 mice	1500 mg/kg/day	Muscular atrophy because of streptozotocin‐induced diabetes	2 weeks	Oral	Improvement of muscular atrophy
84	C57BL/6 mice	5% of daily diet	—	21 days	Oral	Reduced mitochondrial apoptosis No change in mitochondrial biogenesis adaptations in muscles
85	Wistar rats	50–100 mg/kg/day	Endurance exercise training	28 days	Intraperitoneal injection	Increase in cyclic adenosine monophosphate level and mitochondrial biogenesis in skeletal muscles
50	Randomized controlled trial	200 mg twice daily	Downhill running test	4 days	Oral	Reduced muscle pain and significant reduction in muscle injury in the lower limb
58	Randomized controlled trial	2.5 g twice daily	Eccentric single‐leg press exercise	5 days	Oral	Reduced muscular pain