Table 3.
Univariate and multivariate analyses of factors contributing to HCC development.
| Variables | n | Univariate | Multivariate analysis | |
|---|---|---|---|---|
| P value | OR (95% CI) | P value | ||
| Gender, male / female | 215 / 123 | 0.1732 | ||
| Presence of LC, yes / no | 91 / 247 | <0.0001 | 2.603 (1.089-6.476) | 0.0311 |
| Serum albumin ≥3.9 g/dl, yes / no | 247 / 91 | 0.0325 | 0.824 (0.362-1.832) | 0.6367 |
| Total bilirubin ≥1.1 mg/dl, yes / no | 86 / 252 | 0.0043 | 1.150 (0.536-2.421) | 0.7147 |
| APRI ≥0.786, yes / no | 188 / 150 | 0.0027 | 1.037 (0.309-3.460) | 0.9515 |
| FIB-4 index ≥3.666, yes / no | 83 / 255 | <0.0001 | 3.597 (1.421-10.374) | 0.0062 |
| Pretreatment AFP ≥13.2 ng/ml, yes / no | 75 / 263 | 0.0036 | 2.221 (1.074-4.527) | 0.0318 |
| HBV-DNA ≥7.4 log copies/ml, yes / no | 103 / 235 | 0.0098 | 3.846 (1.467-13.227) | 0.0045 |
| HBe antigen positivity, yes / no | 163 / 175 | 0.1209 | ||
OR; hazard ratio, CI; confidence interval, LC; liver cirrhosis, AST; aspartate aminotransferase, ALT; alanine aminotransferase, APRI; AST to platelet ratio index, AFP; alpha-fetoprotein, HBV; hepatitis B virus.