Table 2.
Univariate and multivariate analyses for overall survival in R1-resected esophageal squamous cell carcinoma (n=124).
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OS (median, CI) | P value | Hazard Ratio (CI) | P value | |
| Age (years) | 0.495 | |||
| < 60 | 24.0 (18.1-29.9) | |||
| ≥ 60 | 25.6 (15.4-35.8) | |||
| Sex | 0.444 | |||
| Male | 26.9 (21.0-32.9) | |||
| Female | 24.0 (7.5-40.4) | |||
| ECOG PS | 0.068 | |||
| 0-1 | 26.9 (19.7-34.2) | |||
| 2 | 17.8 (6.6-28.9) | |||
| Weight loss † | ||||
| < 10% | 28.2 (22.6-33.8) | 0.222 | ||
| ≥ 10% | 18.9 (15.5-22.4) | |||
| Tumor Location | 0.877 | |||
| Upper | 22.9 (14.1-31.7) | |||
| Middle | 28.5 (20.1-36.9) | |||
| Lower | 26.9 (18.0-35.6) | |||
| Multiple | 45.3 | |||
| pT stage | 0.515 | |||
| T1,2 | 32.8 (2.7-62.9) | |||
| T3,4 | 24.0 (18.8-29.3) | |||
| pN stage | 0.028 | 0.004 | ||
| N0 | 29.5 (10.5-48.5) | 1 | ||
| N1-3 | 23.0 (15.0-31.0) | 2.192 (1.284-3.742) | ||
| pTNM stage | 0.091 | |||
| Ia, b+IIa, b | 29.5(11.6-47.3) | |||
| IIIa, b, c | 24.0 (20.4-30.8) | |||
| Surgical technique | 0.365 | |||
| Ivor Lewis | 17.7 (0-36.3) | |||
| McKeown | 28.2 (19.4-37.1) | |||
| Laparotomy + left thoracotomy | 25.6 (19.4-31.8) | |||
| Adjuvant CT | 0.032 | 0.004 | ||
| No | 20.5 (13.6-27.5) | 1 | ||
| Yes | 32.5 (22.2-42.9) | 0.481 (0.291-0.794) | ||
| Adjuvant RT | 0.439 | |||
| No | 23.0 (15.2-30.8) | |||
| Yes | 29.5 (21.0-38.0) | |||
† Weight loss was assessed over a 6-month period prior to surgery;
CT: chemotherapy; RT: radiotherapy.