Table 4.
Univariate and multivariate analyses for locoregional recurrence-free survival in R1-resected esophageal squamous cell carcinoma (n=93).
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| 1-year LRFS (%) | P value | Hazard Ratio (95% CI) | P value | |
| Age (years) | 0.826 | |||
| <60 | 68.2 | |||
| ≥60 | 85.0 | |||
| Sex | 0.930 | |||
| Male | 73.7 | |||
| Female | 76.6 | |||
| ECOG PS | 0.059 | |||
| 0-1 | 76.6 | |||
| 2 | 41.7 | |||
| Weight loss † | 0.104 | |||
| <10% | 77.6 | |||
| ≥10% | 66.7 | |||
| Tumor Location | 0.712 | |||
| Upper | 77.8 | |||
| Middle | 73.9 | |||
| Lower | 74.0 | |||
| Multiple | 75.0 | |||
| pT stage | 0.228 | |||
| T1,2 | 65.4 | |||
| T3,4 | 73.5 | |||
| pN stage | 0.029 | 0.009 | ||
| N0 | 80.5 | 1 | ||
| N1-3 | 71.3 | 2.567 (1.270-5.189) | ||
| pTNM stage | 0.103 | |||
| Ia, b+IIa, b | 77.2 | |||
| IIIa, b, c | 72.1 | |||
| Surgical technique | 0.179 | |||
| Ivor Lewis | 72.9 | |||
| McKeown | 78.4 | |||
| Laparotomy + left thoracotomy | 72.1 | |||
| Adjuvant CT | 0.685 | |||
| No | 69.4 | |||
| Yes | 78.3 | |||
| Adjuvant RT | 0.000 | 0.000 | ||
| No | 61.1 | 1 | ||
| Yes | 90.7 | 0.278 (0.141-0.548) | ||
† Weight loss was assessed over a 6-month period prior to surgery;
CT: chemotherapy; RT: radiotherapy.