Table 4. Multivariable linear regression models showing the association between standard deviation increments in eGFR (independent variable, in ml/min/1.73 m2 body surface area (BSA)) and cathepsin-S (dependent variable, in ng/ml) in all three study cohorts.
Study group | regression coefficient B | 95% confidence intervals | p-value |
---|---|---|---|
MCKD | −1.008 | −1.576–(−0.439) | <0.001 |
ULSAM | −0.664 | −0.952–(−0.375) | <0.001 |
PIVUS | −1.076 | −1.604–(−0.547) | <0.001 |
Multivariable analysis adjusted for age, gender, body-mass-index and c-reactive protein; the regression coefficient B describes the change of cathepsin-S (in ng/ml) per change of one standard deviation (SD) of eGFR in every cohort (SD in MCKD 37.2 ml/min/1.73 m2 BSA, in ULSAM 17.1 ml/min/1.73 m2 BSA, in PIVUS 19.3 ml/min/1.73 m2 BSA).