Fig. (3).

Rapastinel is a cognitive enhancer. (A-C) The effects of an optimal cognitive enhancing dose of rapastinel (1 mg/kg, IV, 15 min post-dosing) in young adult (3 months) or learning-impaired aged (27 month old) rats in hippocampal dependent trace eyeblink conditioning (A), alternating T-maze (B), and Morris water maze (C) tests. (D) GLYX-13 (1 mg/kg, IV, 15 min post-dosing) in young adult (3 months) rats facilitated positive emotional learning as measured by rates of hedonic 50-kHz USVs in response to a conditioned stimulus that predicts heterospecific rough-and-tumble play. Data are expressed as Mean ± SEM. * P<0.05 Fisher's PLSD post hoc test vs. vehicle. Data adapted with permission from [14, 25, 26].