Fig. (4).

Rapastinel has antidepressant-like properties without psychotomimetic side effects in rats. (A-D) The antidepressant-like effects of an optimal antidepressant-like dose of rapastinel (3 mg/kg, IV) in the rat Porsolt test measured at 1 hr (A) or 24 hrs (B) post-dosing, the novelty induced hypophagia test 1 hr post-dosing (C), or the learned helplessness test 24 hrs post dosing (D). Rapastinel does not show ketamine-like discriminative stimulus effects (E) or sedative effects (F) in rats trained to discriminate 10 mg/kg ketamine from saline. (G-H) Rapastinel (10 mg/kg, IV) does not show ketamine-like rewarding effects in the conditioned place preference (G), or sensory-motor gating deficits in the pre-pulse inhibition (H) tests in rats. Data are expressed as Mean ± SEM. * P<0.05 Fisher's PLSD post hoc test vs. vehicle. Data adapted with permission from [27].