Fig. (1).

Association between bioluminescence signal and corresponding tumor volume in rats receiving brainstem injection of patient-derived DIPG cells. A) Implantation of tumor cells in the rodent pons is detectable with BLI. B) MR imaging shows high signal within the pons, similar to the human imaging study. C) The histopathology shows a diffusely infiltrating tumor occupying the pons; once again similar to the human tissue sample. D) Immunohistochemistry demonstrates that the tumor cells are positive for GFAP, Nestin, Olig2 (scattered), and PDGFRI (reprinted by permission).