Fig. (1).

Illustration demonstrating convection-enhanced delivery (CED) in the treatment of diffuse intrinsic pontine glioma (DIPG). An infusion cannula is inserted through the transfrontal extraventricular approach into the pons. The tip of the cannula will be at or near the center of the tumor. This is achieved by image-guided high-precision stereotaxy. With the cannula in place, drugs are infused into the pons driven by a precision pump. Ideally, the drug infused area encompasses the tumor and the surrounding infiltrated area.