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. 2017 Feb 27;7:43409. doi: 10.1038/srep43409

Figure 12. The role and molecular mechanism of p53 in UUO-induced renal fibrosis.

Figure 12

TGF-β1 increased miR-199a-3p expression by induction of p53. Furthermore, miR-199a-3p directly suppressed SOCS7 expression, which led to activation of STAT3 and upregulation of the production of probrotic proteins.