Table 4.
The relationship between epigenetic measurements and asthma health outcomes in ARTIS
| Epigenetic marker | dPFV | % Predicted morning FEV1 | % Predicted evening FEV1 | PAQLQ | ||||
|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) | q-value | Estimate (95% CI) | q-value | Estimate (95% CI) | q-value | Estimate (95% CI) | q-value | |
| LINE-1 | 1.24 (0.31, 2.16) | 0.16* | −0.89 (−3.18, 1.41) | 0.80 | −1.19 (−3.41, 1.03) | 0.72 | 0.04 (−0.11, 0.20) | 0.84 |
| IFNγ CpG-186 | 0.58 (0.06, 1.09) | 0.29 | −0.53 (−1.79, 0.72) | 0.77 | −0.57 (−1.62, 0.48) | 0.72 | 0.03 (0.00, 0.07) | 0.44 |
| IFNγ CpG-54 | 0.22 (−0.74, 1.19) | 0.87 | −0.57 (−1.92, 0.77) | 0.77 | −0.84 (−2.10, 0.42) | 0.69 | 0.02 (−0.07, 0.11) | 0.85 |
dPFV evening to morning peak flow variability, FEV 1 forced expiratory volume in 1 s, PAQLQ pediatric asthma quality of life questionnaire, IFNγ interferon gamma
* q-value <0.20