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. 2017 Feb 27;16:47. doi: 10.1186/s12943-017-0614-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Mitochondrial DNA sequencing in BOTs and implants (a, b, c, d). Electropherograms of mitochondrial loci harboring mutations in BOT and peritoneal implant samples. Red arrows indicate the mutated bases. (e, f) Representative dHPLC elution profiles for the in-depth investigation of the somatic nature of mitochondrial DNA mutations m.15570 T > Y/MT-CYB in case B1 and m.11984 T > Y/MT-ND4 in case B3. Homo- and hetero-duplexes are distinguished based on different retention times. (e) Two elution curves for T (Tumor) and I (Implant) (heteroduplex and homoduplex) and a single elution curve for non-tumor tissue (N) and three wild-type controls are present in the analysis of m.15570 T > Y/MT-CYB in case B1. Wild-type (black, pink and purple), N (light green), I (green), T (brown). (f) Two elution curves for T and I (heteroduplex and homoduplex) and a single elution curve for non-tumor tissue (N) and one wild-type control are present in the analysis of m.11984 T > Y/MT-ND4 in case B3. Wild-type (black), N (light green), I (green), T (brown)