Table 3.
Risk factors for bacteremia-related mortality in ASOT recipients with MDR GNB
| Characteristics | Related mortality | Survival | P | OR (95% CI) |
|---|---|---|---|---|
| Total, n (%) | 36 (39.6) | 55 (60.4) | ||
| Univariate analysis | ||||
| Age ≥ 40 year | 25 (69.4) | 35 (63.6) | 0.568 | |
| Male sex | 24 (66.7) | 38 (69.1) | 0.808 | |
| Temperature ≥ 40 °C | 8 (22.2) | 4 (7.3) | 0.039 | |
| Inappropriate empirical antibiotics | 14 (38.9) | 20 (36.4) | 0.808 | |
| Nosocomial infection | 35 (97.2) | 39 (70.9) | 0.002 | |
| Graft from DCD or deceased donors | 17 (47.2) | 39 (70.9) | 0.023 | |
| Liver transplant | 20 (55.6) | 24 (43.6) | 0.266 | |
| Lung focus | 22 (61.1) | 15 (27.3) | 0.001 | |
| Presence of other concomitant BSIs | 22 (61.1) | 13 (23.6) | <0.001 | |
| Non-fermentative bacteremia | 18 (50.0) | 18 (32.7) | 0.099 | |
| ESBL (+) bacteremia | 31 (86.1) | 42 (76.4) | 0.254 | |
| Carbapenem-resistant bacteremia | 16 (44.4) | 22 (40.0) | 0.674 | |
| Late-onset infection | 12 (33.3) | 17 (30.9) | 0.808 | |
| Septic shock | 28 (77.8) | 5 (9.1) | <0.001 | |
| Platelet count < 50,000/mm3 | 26 (72.2) | 13 (23.6) | <0.001 | |
| Lymphocyte count < 300/mm3 | 17 (47.2) | 15 (27.3) | 0.051 | |
| Albumin < 30 g/L | 11 (30.6) | 5 (9.1) | 0.009 | |
| WBC count > 15,000/mm3 | 12 (33.3) | 15 (27.3) | 0.277 | |
| Creatinine > 1.5 mg/dL | 23 (63.9) | 19 (34.5) | 0.006 | |
| Multivariate analysis | ||||
| Presence of other concomitant BSIs | 0.001 | 27.074 (3.937–186.210) | ||
| Nosocomial infection | 0.033 | 23.963 (1.285–446.991) | ||
| Creatinine > 1.5 mg/dL | 0.001 | 24.498 (3.449–173.998) | ||
| Septic shock | <0.001 | 160.463 (19.377–1328.832) | ||
ASOT abdominal solid organ transplant, DCD donation after cardiac death, ESBL extended-spectrum beta-lactamase, MDR multidrug-resistant, GNB gram-negative bacteria, OR odds ratio, CI confidence interval, BSIs bloodstream infections, WBC white blood cells