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. 2017 Jan 12;7(3):624–633. doi: 10.7150/thno.17484

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Ex vivo analysis of the distribution of hybrid-Cy5-Ac-TZ14011 in tissue sections. A) Color overlay of the ¹⁶⁵Ho-signal intensity map as obtained using LA-ICP-MS on standard photographic images of the whole tissue section (max intensity: 2*10^{4 165}Ho atoms). Individual images were obtained using a 2.5x magnification, the complete overview was obtained after stitching of these images. B) More detailed ¹⁶⁵Ho signal intensity map of the area within the red rectangle. The linearly scaled color bar on the right presents the ¹⁶⁵Ho signal intensity. C) Fluorescence images of consecutive tissue sections at 5x magnification showing a more detailed staining pattern (max pixel intensity: 6*10⁴). Cell nuclei were stained blue using DAPI containing Proline Gold mounting medium.