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. 2017 Jan 15;7(3):664–676. doi: 10.7150/thno.15162

Figure 1.

Figure 1

miR-17-3p Is Increased in Exercise-Induced Physiological Hypertrophy. (A) Heart weight/body weight (HW/BW) and heart weight/tibia length (HW/TL) ratios of sedentary (control) and swum (swim) mice. n=6 per group. (B and C) qRT-PCRs for ANP and BNP (B, n=6 per group), members of the miR-17-92 cluster, and their passenger microRNAs (C, n=5 per group) in sedentary and swum mice. (D) qRT-PCRs for miR-17-3p and miR-18a-3p in sedentary (control) and voluntary wheel-running (run) mice. n=4 per group. (E) qRT-PCRs for miR-17-3p in isolated adult cardiomyocytes (CM) and non-cardiomyocytes (NCM) from sedentary and swum mice. n=4 per group. (F) qRT-PCRs for miR-17-3p in skeletal muscle from sedentary and swum mice. n=5 per group. (G) qRT-PCRs of tissue distribution of miR-17-3p. n=5 per group. (H and I) qRT-PCRs for miR-17-3p in hearts from transverse aortic constriction (TAC)-induced pathological hypertrophy and human dilated cardiomyopathy (DCM) heart samples. n=5 for mice per group and n=4 for human per group. (J) qRT-PCRs for miR-17-3p in serum from chronic heart failure patients (n=28) before and after acute exercise training. *, P<0.05, **, P<0.01, ***, P<0.001 versus respective control.