Figure 8.

Inhibition of Cell Proliferation and Induction of Apoptotic Cell Death by PMMNCs-miR-100 (nano-miR-100) delivery in PDXs. (A) The FGFR3 protein expression in PDXs with indicated treatment was determined by Western blot analysis (left) and further normalized on the expression level of vehicle treatment group (right). (B~C) Quantification (B) and representative tumor tissue sections (C) stained for FGFR3, Ki67, and Caspase 3 expression by immunohistochemistry. Original magnification: 20×. The PDXs treated as indicated were collected and processed 2 hrs after the final treatments. All error bars indicate standard deviation. N.S., no statistical signification; *, p<0.01 versus the control group.