Figure 2.

Characterization of CD44 targeted liposomal nanoparticles. A. The TEM image of NPs-Dox. The diameter was approximately 100 nm and the sizes of the nanoparticles were uniform. B. Representative DLS measurement for size distribution of NPs-Dox. C. The characterizations of the eight nanoparticles. Data were presented as the mean ± standard error of the mean (SEM, n = 3). D. The encapsulation efficiency, drug loading efficiency or quantity of Dox and anti-IL6R Ab-PE in the liposomal nanoparticles. Data were presented as the mean ± standard deviation (SD, n = 4). In vitro release profiles of Dox (E) and anti-IL6R Ab-PE (αIL6R Ab-PE, F) from nanoparticles under different pH values at 37℃. Data were presented as the mean + SD, n = 4.