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. 2017 Jan 26;7(3):775–788. doi: 10.7150/thno.17237

Figure 6.

Figure 6

Inhibited IL6R-Stat3 signaling in primary tumour and reduced CSCs-like population in lung metastatic foci of MMTV-PyMT mice treated with NPs-αIL6R Ab-CD44. A. IHC staining of Stat3, p-Stat3, MMP-9, VEGFA, CD31, Sox2 and CD206 in primary tumour tissues of MMTV-PyMT mice, which were treated with PBS, αIL6R Ab, NPs-IgG-CD44, NPs-αIL6R Ab and NPs-αIL6R Ab-CD44, respectively. B. The statistical results of IHC staining for Stat3, p-Stat3, MMP-9, VEGFA, CD31, Sox2 and CD206 in the primary tumour of MMTV-PyMT mice. Data were presented as the mean ± SEM, n = 6 mice. C. IHC staining of Sox2 and CD206 in the lung metastatic foci of MMTV-PyMT mice. D. Statistical analysis for the percentage of Sox2+ and CD206+ cells in the lung metastatic foci. Data were presented as mean + SEM, n = 6 mice.