FIGURE 3.

(Top) Schematic representation of the network-based indirect response model to MPL (D). Once the drug-receptor complex translocates into the nucleus (DR_n), it induces its effects on the transcription of its target genes (mRNA₁, mRNA₂) either by stimulation (open rectangle) or by inhibiting it (closed rectangle). (Bottom) When transcribed messages are translated to the active proteins (Protein₁, Protein₂), they can also have effects, either stimulatory (green) or inhibitory (red), on the transcription of target genes affected by MPL. All these effects are considered as indirect as there might be additional biological processes in between.