Table 1.
Sample sizes and racial/ethnic composition of the WHI GWAS studiesa
| Study Name | Study population (synopsis) |
GWAS method | Link to further information on dbgapb |
|---|---|---|---|
|
| |||
| SHARe AA & H GWAS SNP Health Association Resource | African American (AA) and Hispanic (H) participants in the WHI CT or OS | Affymetrix 6.0 | http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000386.v6.p3 |
| Racial/ethnic distribution: 70% AA, 30% H | |||
|
| |||
| GARNET HT GWAS: Genomics and Randomized Trials Network | Cases and controls from the WHI HT trials | Illumina HumanOmni1-Quad v1-0 B | http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000315.v6.p3 |
| Cases: all of the WHI participants with confirmed cases of CHD, stroke, VTE, or incident diabetes, or more than one of the case conditions in the WHI HT trials. | |||
| Controls: free of those conditions by the end of the WHI HT trials. | |||
| Racial/ethnic distribution: white (87%), black (5%), Hispanic (3%), Asian/Pacific Islander (1.8%), American Indian (0.7%), unknown (1.9%) | |||
|
| |||
| WHIMS + EA GWAS | WHI HT Trial participants of non- Hispanic European ancestry from 3 subgroups: | Illumina HumanOmniExpress Exome-8v1_B | http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000675.v2.p3 |
| WHIMS = WHIMemory Study cohort | 1) WHI Memory Study (WHIMS) participants who were not in GARNET | ||
| 2) Women at least 65 years old at enrollment who were neither in WHIMS nor GARNET | |||
| 3) Women younger than age 65 at enrollment who were neither in WHIMS nor GARNET | |||
| Racial/ethnic distribution: non-Hispanic European ancestry | |||
a
All participants were postmenopausal women. Further information regarding the Genome Wide Association Studies (GWAS) within the Women’s Health Initiative (WHI) Clinical Trials and Observational Studies is available at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000746.v1.p3 and at https://www.whi.org/researchers/data/SitePages/GWAS%20Data.aspx. QC denotes quality control, CHD denotes coronary heart disease (myocardial infarction or coronary death), VTE denotes venous thromboembolism, and HT denotes menopausal hormone therapy.
b
dbGAP denotes the Database of Genotype and Phenotype created by the National Center for Biotechnology Information (NCBI).