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. 2017 Feb 21;12:1385–1399. doi: 10.2147/IJN.S125300

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© 2017 Singleton et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License

The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Distribution of P407-rhodamine nano-micelles after CED into rat corpus callosum (white matter) and striatum (gray matter).

Notes: (A) White matter distribution 0 hour after CED. (B) Gray matter distribution 0 hour after CED. (C) White matter distribution 48 hours after CED. (D) Gray matter distribution 48 hours after CED. Volume of infusion (Vi) is calculated by auto-segmentation of fluorescent signal (white image) from images from adjacent 35 μm brain sections using bespoke in-house software. Volume of distribution to volume of infusion ratio (Vd/Vi) indicates bulk flow of micelles via CED rather than simple injection.

Abbreviations: CED, convection enhanced delivery; P407, poloxamer 407.