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. 2017 Feb 21;12:1385–1399. doi: 10.2147/IJN.S125300

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© 2017 Singleton et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License

The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Toxicity of P407 nano-micelles.

Notes: (A) In vitro morphology of a mixed primary rat glio-neuronal culture after 72 hours of incubation with 5% P407 in aCSF relative to control. (B) Synaptophysin ELISA of protein isolated from rat brain 21 days after infusion of either aCSF or P407/aCSF nano-micelles and from untreated tumor-bearing animals (one-way ANOVA Bonferroni’s multiple comparison test, P>0.05). (C) Immunofluorescent microscopy of fixed rat brain for neurons (NeuN) and glia (GFAP) 21 days after acute striatal infusion of either aCSF or P407/aCSF nano-micelles.

Abbreviations: aCSF, artificial cerebrospinal fluid; ANOVA, analysis of variance; DAPI, 4,6-Diamidino-2-phenylindole, dihydrochloride; ELISA, enzyme-linked immunosorbent assay; NS, not significant; P407, poloxamer 407.