Table S1.
Patient comorbidity profile
| Overall
|
5EU
|
USA
|
China
|
|
|---|---|---|---|---|
| (N=2,166) | (n=1,242) | (n=413) | (n=511) | |
| Cardiovascular condition, n (%) | ||||
| Missing, n | 57 | 42 | 10 | 5 |
| Angina pectoris | 111 (5.3) | 91 (7.6) | 9 (2.2) | 11 (2.2) |
| Cardiac arrhythmias | 165 (7.8) | 108 (9.0) | 22 (5.5) | 35 (6.9) |
| Coagulated blood clotting disorder | 18 (0.9) | 10 (0.8) | 5 (1.2) | 3 (0.6) |
| Congestive heart failure | 105 (5.0) | 59 (4.9) | 34 (8.4) | 12 (2.4) |
| Coronary artery disease | 179 (8.5) | 70 (5.8) | 50 (12.4) | 59 (11.7) |
| Elevated cholesterol/hyperlipidemia | 569 (27.0) | 328 (27.3) | 170 (42.2) | 71 (14.0) |
| Hypertension | 1,176 (55.8) | 728 (60.7) | 269 (66.8) | 179 (35.4) |
| Myocardial infarction | 81 (3.8) | 65 (5.4) | 8 (2.0) | 8 (1.6) |
| Peripheral vascular disease | 106 (5.0) | 66 (5.5) | 37 (9.2) | 3 (0.6) |
| Pulmonary arterial hypertension | 51 (2.4) | 24 (2.0) | 7 (1.7) | 20 (4.0) |
| Cerebrovascular disease and/or stroke | 46 (2.2) | 26 (2.2) | 10 (2.5) | 10 (2.0) |
| Thrombosis | 21 (1.0) | 10 (0.8) | 4 (1.0) | 7 (1.4) |
| Other CV condition | 32 (1.5) | 24 (2.0) | 4 (1.0) | 4 (0.8) |
| None | 679 (32.2) | 346 (28.8) | 86 (21.3) | 247 (48.8) |
| Physician-confirmed serious CV conditiona, n (%) | ||||
| Missing, n | 57 | 42 | 10 | 5 |
| Serious CV | 574 (27.2) | 334 (27.8) | 118 (29.3) | 122 (24.1) |
| Other concomitant conditionsb, n (%) | ||||
| Missing, n | 196 | 45 | 20 | 131 |
| None | 275 (14.0) | 253 (21.1) | 22 (5.6) | 0 |
| AIDS/HIV | 5 (0.3) | 4 (0.3) | 0 | 1 (0.3) |
| Anemia | 63 (3.2) | 24 (2.0) | 14 (3.6) | 25 (6.6) |
| Anxiety | 223 (11.3) | 128 (10.7) | 70 (17.8) | 25 (6.6) |
| Arthritis | 271 (13.8) | 109 (9.1) | 110 (28.0) | 52 (13.7) |
| Atopic dermatitis | 10 (0.5) | 5 (0.4) | 3 (0.8) | 2 (0.5) |
| Cancer | 44 (2.2) | 30 (2.5) | 11 (2.8) | 3 (0.8) |
| Crohn’s disease | 12 (0.6) | 10 (0.8) | 1 (0.3) | 1 (0.3) |
| Connective tissue/rheumatologic disease | 12 (0.6) | 3 (0.3) | 6 (1.5) | 3 (0.8) |
| Dementia | 18 (0.9) | 10 (0.8) | 5 (1.3) | 3 (0.8) |
| Depression | 184 (9.3) | 121 (10.1) | 60 (15.3) | 3 (0.8) |
| Dermatitis/eczema | 18 (0.9) | 6 (0.5) | 4 (1.0) | 8 (2.1) |
| Diabetes | 305 (15.5) | 208 (17.4) | 54 (13.7) | 43 (11.3) |
| Dyspepsia/stomach pain | 121 (6.1) | 40 (3.3) | 13 (3.3) | 68 (17.9) |
| Gastroesophageal reflux disease | 217 (11.0) | 121 (10.1) | 89 (22.7) | 7 (1.8) |
| Glaucoma | 43 (2.2) | 26 (2.2) | 10 (2.5) | 7 (1.8) |
| Hyperthyroidism | 28 (1.4) | 21 (1.8) | 6 (1.5) | 1 (0.3) |
| Liver disease | 46 (2.3) | 33 (2.8) | 5 (1.3) | 8 (2.1) |
| Obesity | 155 (7.9) | 112 (9.4) | 32 (8.1) | 11 (2.9) |
| Osteoporosis | 167 (8.5) | 86 (7.2) | 36 (9.2) | 45 (11.8) |
| Prostate disorder | 168 (8.5) | 122 (10.2) | 38 (9.7) | 8 (2.1) |
| Psoriasis | 11 (0.6) | 6 (0.5) | 2 (0.5) | 3 (0.8) |
| Peptic ulcer disease | 57 (2.9) | 15 (1.3) | 6 (1.5) | 36 (9.5) |
| Renal failure | 40 (2.0) | 31 (2.6) | 3 (0.8) | 6 (1.6) |
| Sinusitis | 58 (2.9) | 11 (0.9) | 9 (2.3) | 38 (10.0) |
| Sleep apnea | 102 (5.2) | 59 (4.9) | 30 (7.6) | 13 (3.4) |
Notes:
a
Serious CV is defined as conditions such as angina and congestive heart failure and excludes the CV risk factors hypertension and hyperlipidemia;
b
concomitant conditions list is not exhaustive. All variables are physician reported, with the exception of employment status.
Abbreviations: 5EU, France, Germany, Italy, Spain and the UK; AIDS, acquired immunodeficiency syndrome; CV, cardiovascular; HIV, human immunodeficiency virus.