Table 1.
Patient demographics and clinical characteristics
| Overall
|
5EU
|
USA
|
China
|
|
|---|---|---|---|---|
| (N=2,166, 100%) | (n=1,242, 57.3%) | (n=413, 19.1%) | (n=511, 23.6%) | |
| Age | ||||
| Missing, n | 0 | 0 | 0 | 0 |
| Mean (SD) | 65.1 (10.7) | 65.3 (10.4) | 67.2 (9.9) | 62.7 (11.6) |
| Age, n (%) | ||||
| <65 years | 985 (45.5) | 540 (43.4) | 158 (38.3) | 287 (56.2) |
| ≥65 years | 1,181 (54.5) | 702 (56.5) | 255 (61.7) | 224 (43.8) |
| Gender, n (%) | ||||
| Missing, n | 0 | 0 | 0 | 0 |
| Male | 1,442 (66.6) | 896 (72.1) | 229 (55.5) | 317 (62.0) |
| Race, n (%) | ||||
| Missing, n | 4 | 4 | 0 | 0 |
| Caucasian | 1,533 (70.9) | 1,176 (95.0) | 357 (86.4) | 0 |
| African | 35 (1.6) | 0 | 35 (8.5) | 0 |
| American | ||||
| Hispanic | 45 (2.1) | 33 (2.7) | 12 (2.9) | 0 |
| Asian–Indian | 9 (0.4) | 5 (0.4) | 4 (1.0) | 0 |
| Subcontinent | ||||
| Asian–other | 9 (0.4) | 4 (0.3) | 5 (1.2) | 0 |
| Chinese | 511 (23.6) | 0 | 0 | 511 (100.0) |
| Other | 20 (0.9) | 20 (1.6) | 0 | 0 |
| BMI | ||||
| Missing, n | 95 | 66 | 28 | 1 |
| Mean (SD) | 25.6 (4.6) | 26.0 (4.3) | 27.5 (5.9) | 23.3 (3.0) |
| Employment status, n (%) | ||||
| Missing, n | 38 | 24 | 12 | 2 |
| Employed | 529 (24.9) | 297 (24.4) | 118 (29.4) | 114 (22.4) |
| Retired | 1,263 (59.4) | 713 (58.5) | 209 (52.1) | 341 (67.0) |
| Homemaker | 113 (5.3) | 65 (5.3) | 23 (5.7) | 25 (4.9) |
| Unemployed | 152 (7.1) | 97 (8.0) | 26 (6.5) | 29 (5.7) |
| On long-term disability | 71 (3.3) | 46 (3.8) | 25 (6.2) | 0 |
| Smoking status, n (%) | ||||
| Missing, n | 11 | 1 | 2 | 8 |
| Current smoker | 629 (29.2) | 417 (33.6) | 132 (32.1) | 80 (15.9) |
| Ex-smoker | 1,232 (57.2) | 755 (60.8) | 260 (63.3) | 217 (43.1) |
| Never smoked | 294 (13.6) | 69 (5.6) | 19 (4.6) | 206 (41.0) |
| Pack-years | ||||
| Missing, n | 79 | 48 | 22 | 9 |
| Mean (SD) | 30.0 (23.9) | 34.9 (23.3) | 35.1 (24.8) | 14.7 (17.1) |
| Pack-years (grouped), n (%) | ||||
| Missing, n | 79 | 48 | 22 | 9 |
| <10 | 414 (19.8) | 136 (11.4) | 40 (10.2) | 238 (47.4) |
| ≥10 | 1,673 (80.2) | 1,058 (88.6) | 351 (89.8) | 264 (52.6) |
| Most recent FEV1 test score (post-bronchodilator), % predicted | ||||
| Missing, n | 1,287 | 657 | 251 | 379 |
| Mean (SD) | 61.9 (18.2) | 64.0 (18.1) | 62.1 (17.3) | 52.0 (16.9) |
| Mean number of exacerbations treated with OCS, antibiotics, both, ED or hospitalization in the last 12 months (5EU + US only) | ||||
| Missing, n | 536 | 16 | 9 | 511 |
| Mean (SD) | 1.3 (1.7) | 1.3 (1.6) | 1.2 (1.8) | – |
| Frequency of exacerbations treated with OCS, antibiotics, both, ED or hospitalization in the last 12 months (5EU + US only), n (%) | ||||
| Missing, n | 536 | 16 | 9 | 511 |
| 0 | 728 (44.7) | 518 (42.3) | 210 (52.0) | – |
| 1 | 320 (19.6) | 253 (20.6) | 67 (16.6) | – |
| 2 | 284 (17.4) | 224 (18.3) | 60 (14.9) | – |
| ≥3 | 298 (18.3) | 231 (18.8) | 67 (16.6) | – |
Abbreviations: 5EU, France, Germany, Italy, Spain and the UK; BMI, body mass index; ED, emergency department; FEV1, forced expiratory volume in 1 second; OCS, oral corticosteroid; SD, standard deviation.