Table 1.
Groups | α (Gy−1)
|
β (Gy−2)
|
LD50 (Gy)
|
DEF
|
R2
|
|||||
---|---|---|---|---|---|---|---|---|---|---|
CHO | HT-29 | CHO | HT-29 | CHO | HT-29 | CHO | HT-29 | CHO | HT-29 | |
IR | 0.064±0.016 | 0.09±0.013 | 0.024±0.002 | 0.021±0.002 | 4.19 | 3.97 | – | – | 0.997 | 0.997 |
GNPs+IR | 0.099±0.018 | 0.144±0.013 | 0.025±0.003 | 0.018±0.002 | 3.63 | 3.37 | 1.15 | 1.17 | 0.996 | 0.998 |
GNPs (24 h)+IR | 0.17±0.017 | 0.213±0.013 | 0.019±0.003 | 0.016±0.002 | 3.03 | 2.69 | 1.38 | 1.47 | 0.997 | 0.998 |
EP+IR | 0.145±0.02 | 0.174±0.024 | 0.02±0.003 | 0.021±0.004 | 3.27 | 2.92 | 1.28 | 1.36 | 0.996 | 0.998 |
GNPs+EP+IR | 0.27±0.02 | 0.439±0.022 | 0.021±0.004 | 0.008±0.004 | 2.18 | 1.52 | 1.92 | 2.61 | 0.995 | 0.998 |
GNPs (24 h)+EP+IR | 0.319±0.02 | 0.487±0.029 | 0.028±0.003 | 0.011±0.005 | 1.85 | 1.37 | 2.26 | 2.89 | 0.998 | 0.997 |
Note: The values are expressed as mean ± SEM.
Abbreviations: LD50, 50% lethal dose; CHO, Chinese hamster ovary; IR, ionizing radiation; GNPs, gold nanoparticles; EP, electroporation; DEF, dose enhancement factor; SEM, standard error of mean.