Figure 4.

Effect of simvastatin on protein synthesis of MMPs and TIMPs.

Notes: Lung tissue section was immunostained for MMP-8, MMP-9, MMP-12, TIMP-1, and TIMP-4. (A–C) MMP-8; (D–F) MMP-9; (G–I) MMP-12; (J–L) TIMP-1; and (M–O) TIMP-4. (A, D, G, J, M) Control animal lungs; (B, E, H, K, N) cigarette smoke exposure animal lungs; and (C, F, I, L, O) animals exposed to cigarette smoke plus simvastatin treatment. Data presented were one representative image data. Magnification: 200×.

Abbreviations: MMP, matrix metalloproteinase; TIMP, tissue inhibitor of MMP.