Table 4.
Formulation # | Entrapment efficiency (%) | Apparent permeability (cm/s) |
---|---|---|
Tenofovir solution A | – | 3.71E−07 ± 1.21E−07 |
Formulation A | 39.8 ± 8.09 | 4.18E−06 ± 1.92E−07 |
Formulation B | 68.1 ± 2.55 | 1.19E−06 ± 1.51E−07 |
Notes: Formulations were prepared using 50 mg cholesterol, either 7.5% (formulation A) or 15% (formulation B) stearylamine as a positive charge imparting agent and an amount of phospholipon 100H to make a total lipid pool of 150 mg. Tenofovir solution A was prepared in correspondence to the EF value of Formulation A in isotonic phosphate buffer.
Abbreviation: EF, entrapment efficiency.