Table 4.

Entrapment efficiency and apparent permeability (Caco-2 transwells, n = 4) data for tenofovir liposomal formulations

Formulation #	Entrapment efficiency (%)	Apparent permeability (cm/s)
Tenofovir solution A	–	3.71E−07 ± 1.21E−07
Formulation A	39.8 ± 8.09	4.18E−06 ± 1.92E−07
Formulation B	68.1 ± 2.55	1.19E−06 ± 1.51E−07

Notes: Formulations were prepared using 50 mg cholesterol, either 7.5% (formulation A) or 15% (formulation B) stearylamine as a positive charge imparting agent and an amount of phospholipon 100H to make a total lipid pool of 150 mg. Tenofovir solution A was prepared in correspondence to the EF value of Formulation A in isotonic phosphate buffer.

Abbreviation: EF, entrapment efficiency.