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. Author manuscript; available in PMC: 2017 Feb 27.
Published in final edited form as: Cell Rep. 2017 Feb 14;18(7):1713–1726. doi: 10.1016/j.celrep.2017.01.055

Figure 6. Proposed model of the Sin3a/HDAC complex in maintaining ESC self-renewal and promoting somatic cell reprogramming through functional cooperation with Nanog.

Figure 6

(A) Nanog and the Sin3a/HDAC complex co-occupy promoter regions of highly expressed pluripotency genes in ESCs and cooperate to promote ESC self-renewal.

(B) Nanog and the Sin3a/HDAC complex functionally cooperate in pre-iPSCs by directly activating pluripotency genes and repressing reprogramming barrier genes resulting in significantly enhanced reprogramming efficiency.