Table 1.
Baseline demographics, clinical and laboratory data
| Variable | Control (32) | Orlistat (45) | P-value |
|---|---|---|---|
| Age (years) | 42.44±9.23 | 40.9±10.7 | 0.40 |
| Body weight (kg) | 84.53±4.75 | 85.79±5.46 | 0.291 |
| BMI (kg/m2) | 29.99±1.52 | 30.70±1.56 | 0.052 |
| Gender (%, M/F) | 56.25/43.75 | 53.33/46.66 | 0.803 |
| Smoking (%) | 12.5 | 13.33 | 0.080 |
| Family history of obesity (%) | 15.62 | 17.77 | 0.660 |
| SBP (mmHg) | 127.0±13.3 | 129.0±9.60 | 0.257 |
| DBP (mmHg) | 81.43±5.63 | 82.92±4.66 | 0.238 |
| Waist (m) | 1.01±0.04 | 1.01±0.05 | 0.795 |
| Waist/hip ratio | 0.95±0.03 | 0.96±0.021 | 0.426 |
| FPG (mmol/L) | 4.91±0.27 | 4.93±0.30 | 0.695 |
| PPG (mmol/L) | 6.69±0.48 | 6.47±0.67 | 0.125 |
| HbA1c (%) | 5.49±0.25 | 5.45±0.24 | 0.452 |
| Insulin (pmol/L) | 98.66±22.46 | 95.97±24.51 | 0.625 |
| HOMA-IR | 3.10±0.75 | 3.05±0.86 | 0.796 |
| TC (mmol/L) | 5.56±0.38 | 5.30±0.82 | 0.099 |
| TG (mmol/L) | 2.14 (2.01–2.43) | 2.17 (1.72–2.21) | 0.083 |
| LDL (mmol/L) | 3.61±0.35 | 3.42±0.71 | 0.163 |
| HDL (mmol/L) | 0.91±0.07 | 0.90±0.64 | 0.632 |
| ALT (ukat/L) | 0.88±0.21 | 0.91±0.21 | 0.577 |
| AST (ukat/L) | 0.57 (0.45–0.61) | 0.53 (0.47–0.69) | 0.872 |
| Bilirubin (µmol/L) | 14.84±4.56 | 13.85±5.66 | 0.413 |
| Periostin (ng/mL) | 1,452.65±350.83 | 1,479.63±393.33 | 0.757 |
| Adiponectin (µg/mL) | 5.50±1.26 | 5.90±1.66 | 0.257 |
| TNF-α (pg/mL) | 6.09±1.68 | 6.79±1.80 | 0.087 |
| IL-6 (pg/mL) | 4.51±1.98 | 3.95±1.97 | 0.221 |
Note: Data are expressed as mean ± standard deviation, % or median (interquartile range).
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; DBP, diastolic blood pressure; F, female; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; ukat, unit for catalytic activity; HOMA-IR, homeostasis model assessment-estimated insulin resistance; IL-6, interleukin-6; LDL, low-density lipoprotein; M, male; PPG, postprandial glucose; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; TNF-α, tumor necrosis factor alpha.