Table 3.
Comparison of pre- and postclinical and laboratory variables within and between groups
| Variable | Control baseline | Control post | P-value | Orlistat baseline | Orlistat post | P-value | P-value between groups |
|---|---|---|---|---|---|---|---|
| Body weight (kg) | 84.53±4.75 | 80.45±4.55 | <0.001** | 85.79±5.46 | 79.49±5.29 | <0.001** | <0.001$ |
| BMI (kg/m2) | 30±1.52 | 28.54±1.50 | <0.001** | 30.70±1.56 | 28.44±1.47 | <0.001** | 0.897 |
| Waist (m) | 1.01±0.04 | 1.00±0.04 | <0.001** | 1.01±0.05 | 0.98±0.04 | <0.001** | <0.001$ |
| Waist/hip ratio | 0.95±0.03 | 0.95±0.02 | 0.718 | 0.96±0.021 | 0.95±0.024 | 0.023* | 0.122 |
| FPG (mmol/L) | 4.91±0.27 | 4.85±0.32 | 0.139 | 4.93±0.30 | 4.81±0.39 | 0.011* | 0.010# |
| PPG (mmol/L) | 6.69±0.48 | 6.67±0.57 | 0.762 | 6.47±0.67 | 6.31±0.71 | 0.066 | 0.080 |
| HbA1c (%) | 5.49±0.25 | 5.47±0.31 | 0.292 | 5.45±0.24 | 5.40±0.28 | 0.122 | 0.010# |
| Insulin (pmol/L) | 98.66±22.46 | 97.94±15.61 | 0.853 | 95.97±24.51 | 88.44±23.79 | 0.012* | 0.042# |
| HOMA-IR | 3.10±0.75 | 3.04±0.56 | 0.623 | 3.05±0.86 | 2.75±0.84 | 0.004* | 0.048# |
| TC (mmol/L) | 5.26±0.48 | 5.07±0.68 | 0.084 | 5.30±0.82 | 5.05±0.75 | 0.005* | 0.020# |
| TG (mmol/L) | 2.14 (2.01–2.43) | 2.08 (1.8–2.3) | 0.022 | 2.17 (1.72–2.21) | 1.95 (1.64–1.95) | <0.001** | 0.007# |
| LDL (mmol/L) | 3.36±0.47 | 3.22±0.65 | 0.179 | 3.42±0.71 | 126.89±0.73 | 0.069 | <0.001$ |
| HDL (mmol/L) | 0.91±0.07 | 0.90±0.08 | 0.515 | 0.90 (0.85–0.96) | 0.94 (0.91–1.01) | <0.001** | 0.029# |
| ALT (ukat/L) | 0.88±0.21 | 0.83±0.18 | 0.103 | 0.91±0.21 | 0.87±0.23 | 0.207 | 0.540 |
| AST (ukat/L) | 0.57 (0.45–0.61) | 0.54 (0.42–0.54) | 0.210 | 0.53 (0.47–0.69) | 0.51 (0.42–0.61) | 0.022* | 0.646 |
| Bilirubin (µmol/L) | 14.84±4.56 | 14.91±5.81 | 0.917 | 13.85±5.66 | 14.02±5.69 | 0.763 | 0.942 |
| Periostin (ng/mL) | 1,452.65±350.83 | 1,446.98±370.36 | 0.750 | 1,479.63±393.33 | 1,398.97±379.78 | 0.002* | 0.030# |
| Adiponectin (µg/mL) | 5.50±1.26 | 5.71±1.33 | 0.068 | 5.90±1.66 | 6.84±1.80 | <0.001** | <0.001$ |
| TNF-α (pg/mL) | 6.09±1.68 | 6.47±1.33 | 0.518 | 6.79±1.80 | 6.29±1.65 | 0.014* | 0.040# |
| IL-6 (pg/mL) | 3.69±1.29 | 3.88±1.32 | 0.268 | 3.95±1.97 | 3.82±1.95 | 0.179 | 0.718 |
Notes: Data are expressed as mean ± standard deviation, % or median (interquartile range),
P-value is <0.001 within groups,
P-value is <0.001 between groups,
P-value is <0.05, within groups,
P-value is <0.05 between groups.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; DBP, diastolic blood pressure; F, female; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; HOMA-IR, homeostasis model assessment-estimated insulin resistance; IL-6, interleukin-6; LDL, low-density lipoprotein; M, male; PPG, postprandial glucose; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; TNF-α, tumor necrosis factor alpha; ukat, unit for catalytic activity.