Table 1.
Definitions of overall toxicity severity levels by grades of individual toxicities. Overall toxicity is scored as the maximum individual severity level. Grades are defined using NCI criteria.
| Overall Toxicity Severity Level (YT) | ||||
|---|---|---|---|---|
|
| ||||
| Mild | Moderate | High | Severe | |
|
|
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| Fatigue | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Nausea | Grade 1 | Grade 2 | Grade 3 | – |
| Neuropathy | – | Grade 1 | Grade 2 | Grade ≥ 3 |
| Hyperglycemia | Grade 2 | Grade 3 | Grade 4 | – |
| Rash | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Diarrhea | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Stomatitis | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Pneumonitis | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Febrile neutropenia | – | – | Grade 3 | Grade 4 |
| Other Non-hematologic | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Hyperlipidemia | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Anemia | Grade 3 | Grade 4 | – | – |
| Thrombocytopenia | Grade 2 | Grade 3 | – | – |
| Neutropenia | Grade 3 | Grade 4 | – | – |
| AST/ALT | Grade 2 | Grade 3 | Grade 4 | – |
| Blindness | – | – | – | Grade 4 |
| Myocardioal Infarction | – | – | – | Grade 4 |
| Stroke | – | – | – | Grade 4 |
| Regimen-Related Death | – | – | – | Grade 5 |