. Author manuscript; available in PMC: 2018 Jan 1.

Published in final edited form as: J R Stat Soc Ser C Appl Stat. 2016 Jun 11;66(1):201–224. doi: 10.1111/rssc.12162

Table 4.

Simulation results for the PDS-GCR-PO model based design. For each dose pair d = (d_M, d_P), Sel = selection percentage and Npat = number of patients treated. Utilities of unacceptable doses have a gray background. The highest utility among acceptable doses is given in boldface.

	Scenario 1	d_P			Scenario 2	d_P
	d_M	40	60	80	d_M	40	60	80

Ū^true(d) Sel, Npat	4	56.0	51.8	48.3	4	43.2	44.4	37.9
	4	32, 9.4	25, 14.8	9, 8.4	4	8, 3.5	17, 12.2	3, 5.3
	5	51.8	47.2	44.7	5	49.7	46.8	38.9
	5	15, 7.4	7, 6.8	2, 3.2	5	28, 8.7	24, 10.5	2, 5.2
	6	48.3	44.7	39.4	6	45.5	39.7	33.6
	6	8, 6.0	2, 2.6	0, 0.9	6	10, 6.7	5, 5.6	0, 1.7
		Percent none selected = 2				Percent none selected = 2

	Scenario 3	d_P			Scenario 5	d_P
	d_M	40	60	80	d_M	40	60	80

Ū^true(d) Sel, Npat	4	39.4	40.1	36.7	4	30.4	44.4	43.7
	4	1, 1.1	3, 8.6	1, 3.2	4	1, 1.2	15, 11.7	9, 6.3
	5	48.9	47.6	42.7	5	44.4	51.3	44.3
	5	12, 6.1	17, 9.1	3, 5.7	5	10, 4.4	39, 12.7	9, 8.5
	6	52.6	49.8	44.6	6	43.7	44.3	39.1
	6	32, 10.0	27, 11.2	3, 4.7	6	6, 4.0	10, 7.8	1, 3.4
		Percent none selected = 1				Percent none selected = 1

	Scenario 8	d_P			Scenario 9	d_P
	d_M	40	60	80	d_M	40	60	80

Ū^true(d) Sel, Npat	4	33.8	45.4	48.2	4	43.8	50.8	52.6
	4	1, 0.8	9, 10.0	15, 7.6	4	1, 0.5	2, 8.3	4, 5.3
	5	37.2		48.953.2	5	50.8	52.6	58.4
	5	2, 2.6	21, 9.7	33, 12.6	5	1, 1.6	4, 5.9	17, 11.5
	6	41.3	45.9	45.6	6	52.6	58.4	64.0
	6	3, 2.5	9, 6.2	6, 7.9	6	4, 3.4	18, 8.6	48, 14.7
		Percent none selected = 1				Percent none selected = 0