Table S2.

Validated and modified PUQE questionnaire

Pregnancy-Unique Quantification of Emesis and Nausea Index
Circle the answer that best suits your situation for the last 12 hours
1. In the last 12 hours, for how long have you felt nauseated or sick to your stomach?
Not at all	≤1 hr	2–3 hr	4–6 hr	>6 hr
(1)	(2)	(3)	(4)	(5)
2. In the last 12 hours, have you vomited or thrown up?
≥7 times	5–6 times	3–4 times	1–2 times	I did not throw up
(5)	(4)	(3)	(2)	(1)
3. In the last 12 hours, how many times have you had retching or dry heaves without bringing anything up?
None	1–2 times	3–4 times	5–6 times	≥7 times
(1)	(2)	(3)	(4)	(5)

Notes: Total score (sum of replies to 1, 2, and 3): mild NVP, ≤6; moderate NVP, 7–12; severe NVP, ≥13. Reprinted from Am J Obstet Gynecol, 186, Koren G, Boskovich R, Hard M, Maltepe C, Navioz Y, Einarson A, Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy, S228–31, 2002, with permission from Elsevier. Copyright © 2002 Published by Mosby, Inc.²

Abbreviation: NVP, nausea and vomiting in early pregnancy.