Table 1.
Signaling pathways modulated in folate nephropathy–associated AKI samples and identified by pathway analysis using KEGG database searching
| KEGG Map | Number of Hits | Name |
|---|---|---|
| mmu04151 | 46 | PI3K-Akt signaling pathway |
| mmu04010 | 29 | MAPK signaling pathwaya |
| mmu04910 | 27 | Insulin signaling pathway |
| mmu04020 | 22 | Calcium signaling pathway |
| mmu04120 | 21 | Ubiquitin mediated proteolysisa |
| mmu04062 | 19 | Chemokine signaling pathwaya |
| mmu04310 | 17 | Wnt signaling pathway |
| mmu04630 | 16 | Jak-STAT signaling pathway |
| mmu04660 | 15 | T cell receptor signaling pathway |
| mmu03320 | 13 | PPAR signaling pathway |
| mmu04064 | 13 | NFκB signaling pathwaya |
| mmu04370 | 11 | VEGF signaling pathway |
| mmu04912 | 11 | GnRH signaling pathway |
| mmu04210 | 11 | Apoptosisa |
| mmu04722 | 10 | Neurotrophin signaling pathway |
a
NFκB activation is at the crossroads of these pathways.