Table 3.

Univariable logistical regression analysis of risk factors for severe renal disease (eGFR<45 ml/min per 1.73 m²) in adults with known common genotypes

Risk Factor	Odds Ratio	Confidence Interval		P Value
		2.5%	97.5%
Genetic factors
Genotype (n=154)
BBS1 mutation (n=90)	(Reference)
BBS2 mutation (n=22)	4.4	1.28	15.19	0.02a
BBS9 mutation (n=6)	2.4	0.12	17.74	0.46
BBS10 mutation (n=26)	7.4	2.49	23.32	<0.01a
BBS12 mutation (n=10)	5.9	1.08	28.39	0.03a
Mutation type (n=149)
Missense/missense (n=76)	(Reference)
Truncating/truncating (n=40)	11.4	3.9	41.8	<0.01a
Missense/truncating (n=33)	6.3	1.5	28.6	0.01a
Diabetes (n=137)	0.62	0.14	0.99	0.47
Hypertension (n=137)	5.43	2.21	14.29	<0.01a
Body mass index (n=93)	1.04	0.96	1.10	0.32
Age (n=154)	1.02	0.99	1.96	0.15

^aStatistically significant result.