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. 2016 Sep 19;28(3):953–962. doi: 10.1681/ASN.2015111230

Table 1.

Baseline characteristics and demographics of randomized patients

Variable Placebo (n=103) TGF-β1 mAb Total (n=416) P-Valuea
2 mg (n=105) 10 mg (n=103) 50 mg (n=105)
Sex, n (%) 0.25
 Men 76 (73.8) 84 (80.0) 74 (71.8) 86 (81.9) 320 (76.9)
 Women 27 (26.2) 21 (20.0) 29 (28.2) 19 (18.1) 96 (23.1)
Age, yr 62.7±11.3 62.8±9.2 60.5±9.1 62.9±10.9 62.2±10.2 0.27
Race, n (%) 0.33
 American Indian or Alaska Native 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 Asian 0 (0.0) 4 (3.8) 2 (1.9) 2 (1.9) 8 (1.9)
 Black 14 (13.6) 9 (8.6) 9 (8.7) 7 (6.7) 39 (9.4)
 Multiple 1 (1.0) 0 (0.0) 2 (1.9) 0 (0.0) 3 (0.7)
 Native Hawaiian or other Pacific Islander 1 (1.0) 0 (0.0) 1 (1.0) 0 (0.0) 2 (0.5)
 White 83 (80.6) 90 (85.7) 84 (81.6) 90 (85.7) 347 (83.4)
 Not provided 4 (3.9) 2 (1.9) 5 (4.9) 6 (5.7) 17 (4.1)
Body mass index, kg/m2 34.0±6.6 33.4±6.0 34.7±7.2 33.3±6.8 33.9±6.7 0.41
Systolic BP, mmHg 139.8±12.3 137.6±14.9 138.2±12.5 136.7±13.6 138.1±1 3.4 0.4
Diastolic BP, mmHg 75.5±8.5 74.2±9.6 74.3±9.0 73.1±9.8 74.3±9.3 0.35
Type 2 diabetes, n (%) 93 (90.3) 92 (87.6) 92 (89.3) 93 (88.6) 370 (88.9) 1.0
Duration of diabetes, d 7073.9 (3381.6) 6610.1 (3324.5) 6957.0 (3069.9) 7110.8 (3686.5)
Duration of kidney disease, d 1922.4 (1405.0) 1802.3 (1655.9) 2041.3 (1527.3) 2133.1 (2318.4)
Hemoglobin A1c, % 7.8±1.8 7.9±1.8 7.9±1.6 7.9±1.7 7.9±1.7 0.96
SCr, mg/dl 2.2±0.6 2.1±0.6 2.1±0.7 2.1±0.6 2.1±0.6 0.57
eGFR, ml/min per 1.73 m2 33.8±11.1 35.7±11.7 36.4±12.5 35.9±12.1 35.5±11.9 0.43
UPCR, g/g 3.1±2.5 3.3±2.6 3.3±2.5 3.4±2.5 3.3±2.5 0.92

Data are means±SD unless otherwise indicated. Summary for SCr was on the basis of the imputed values. Baseline UPCR is the mean of the available values at the last visit obtained on or before the first date of administration of investigational drug. The baseline value for other parameters is the last available value obtained on or before the first date of administration of investigational drug.

a

P values for continuous variables were obtained using one-way ANOVA, with treatment as main effect. P values for categorical variables were obtained using Fisher exact test.

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