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. 2016 Sep 14;28(3):837–851. doi: 10.1681/ASN.2016040414

Figure 7.

Figure 7.

PS-induced stress fiber loss is blocked by inhibition of EGFR, Src, calcineurin, or CatL. (A) Phalloidin staining shows rescue of PS-induced loss of stress fibers by AG1478, SrcI-1, wortmannin, CsA, or E64. (B) Overexpression of GFP-Synpo-Y222A, GFP-Synpo-ED, or GFP-Synpo-CM1+2 but not wild-type GFP-Synpo-short protects against PS-induced stress fiber loss in podocytes; scale bar 20 μm. (C) Quantitative analysis confirms protection by CsA, E64, Synpo-Y222A, Synpo-ED, or SynpoCM1+2. Values are presented as % stress fiber containing cells ±SEM; n=3; ANOVA; ****P<0.001. Molecular mass markers are in kDa.