Skip to main content
. 2016 Nov 23;28(3):726–734. doi: 10.1681/ASN.2016070780

Figure 1.

Figure 1.

Change in serum bicarbonate during hemodialysis correlates directly with dialysate-serum gradient and inversely with predialysis concentration. Intradialytic change in serum bicarbonate versus (A) dialysate–serum bicarbonate gradient and (B) predialysis serum bicarbonate level among chronic hemodialysis patients dialyzed against 35 mEq/L (15 patients, Uribarri et al.); 36 mEq/L (70 patients, Sepandj et al.); and 25, 30, or 35 mEq/L (53 patients, Noh et al.) bicarbonate dialysate. Data from Uribarri et al.,53 Sepandj et al.,54 and Noh et al.52 Intradialytic increase in serum bicarbonate per 1 mEq/L higher predialysis serum bicarbonate = −0.55 mEq/L (95% confidence interval [95% CI], −0.68 to −0.43); for individual studies, the slope was −0.54 mEq/L (95% CI, −0.81 to −0.28) for Uribarri et al., −0.55 mEq/L (95% CI, −0.69 to −0.41) for Sepandj et al., and −0.43 mEq/L (95% CI, −0.66 to −0.20) for Noh et al. P for interaction by study = 0.63.