Figure 2.

Theoretical bicarbonate profiles in hemodialysis. Profiles of serum bicarbonate changes for patients receiving hemodialysis with midweek predialysis serum bicarbonate of 20 and 28 mEq/L, respectively. Profiles assume dialysate bicarbonate of 35 mEq/L and intradialytic increases on the basis of point estimates derived from linear regression of data from Uribarri et al.⁵³ and Sepandj et al.⁵⁴ (predicted intradialytic increase 7.7 mEq/L [95% confidence interval, 7.2 to 8.3] and 2.8 mEq/L [95% confidence interval, 2.1 to 3.5] for predialysis serum bicarbonate of 20 and 28 mEq/L, respectively).