Figure 6.

SP110b upregulates the expression of antiapoptotic genes that are induced by nuclear factor κB. (A) Receptor-interacting protein (RIP1 and RIP3) expression and cleavage levels in the THP1-eGFP-SP110b clonal cell line were characterized by Western blot analysis at the indicated time points post-treatment. (B) FLIP (Fas-associated death domain–like IL-1β–converting enzyme–inhibitory protein), cellular inhibitor of apoptosis protein 1 (cIAP1), cIAP2, X-linked inhibitor of apoptosis protein (XIAP), B-cell lymphoma 2 (BCL2), and B-cell lymphoma–extra large (BCL-XL) expression levels in the THP1-eGFP-SP110b clonal cell line were characterized by Western blot analysis with the indicated antibodies at the respective time points post-treatment. All data are representative of at least two independent experiments. Dox = doxycycline; eGFP = enhanced green fluorescent protein.