Table 2.
Odds Ratios for Epistatic Interactions of Single-Nucleotide Polymorphisms in SP110, NFκB1, and TNFα Genes
| NFκB1: rs230487 | TNFα: rs1800629 | Controls (%) | Cases (%) | OR (95% CI) | P Value | |
|---|---|---|---|---|---|---|
| |
CC |
GG |
68 (33) |
75 (28) |
1.000 |
N/A |
| |
CC |
GA/AA |
12 (6) |
20 (7) |
1.603 (0.657–3.91) |
0.299 |
| |
CA/AA |
GG |
114 (55) |
146 (54) |
1.187 (0.739–1.907) |
0.479 |
| |
CA/AA |
GA/AA |
15 (7) |
31 (11) |
1.756 (0.813–3.794) |
0.152 |
| SP110: rs7580900 | NFκB1: rs230487 | TNFα: rs1800629 | Controls (%) | Cases (%) | OR (95% CI) | P Value |
|---|---|---|---|---|---|---|
| TT |
CC |
GG |
27 (13) |
18 (7) |
1.000 |
N/A |
| TT |
CC |
GA/AA |
4 (2) |
9 (3) |
4.524 (1.033–19.824) |
0.045 |
| TT |
CA/AA |
GG |
38 (18) |
54 (20) |
2.919 (1.244–6.85) |
0.014 |
| TT |
CA/AA |
GA/AA |
9 (4) |
10 (4) |
2.52 (0.752–8.445) |
0.134 |
| CT/CC |
CC |
GG |
41 (20) |
57 (21) |
3.026 (1.304–7.025) |
0.010 |
| CT/CC |
CC |
GA/AA |
8 (4) |
11 (4) |
2.885 (0.823–10.116) |
0.098 |
| CT/CC |
CA/AA |
GG |
75 (36) |
90 (33) |
2.319 (1.064–5.052) |
0.034 |
| CT/CC |
CA/AA |
GA/AA |
6 (3) |
21 (8) |
5.442 (1.646–17.993) |
0.006 |
| SP110: rs7580912 | NFκB1: rs230487 | TNF-α: rs1800629 | Controls (%) | Cases (%) | OR (95% CI) | P Value |
|---|---|---|---|---|---|---|
| TT | CC | GG | 32 (15) | 27 (10) | 1.000 | N/A |
| TT | CC | GA/AA | 6 (3) | 12 (4) | 3.666 (1.039–12.931) | 0.043 |
| TT | CA/AA | GG | 51 (24) | 66 (24) | 2.135 (1.011–4.51) | 0.047 |
| TT | CA/AA | GA/AA | 11 (5) | 14 (5) | 2.067 (0.712–5.999) | 0.182 |
| CT/CC | CC | GG | 36 (17) | 48 (18) | 2.235 (1.014–4.926) | 0.046 |
| CT/CC | CC | GA/AA | 6 (3) | 8 (3) | 1.695 (0.444–6.469) | 0.440 |
| CT/CC | CA/AA | GG | 63 (30) | 78 (29) | 1.706 (0.836–3.479) | 0.142 |
| CT/CC | CA/AA | GA/AA | 4 (2) | 17 (6) | 4.644 (1.27–16.977) | 0.020 |
Definition of abbreviations: CI = confidence interval; N/A = not applicable; NFκB1 = nuclear factor-κ B1; OR = odds ratio; TNF-α = tumor necrosis factor-α.
ORs are adjusted for age and sex. The significant ORs are shown in italic type.